Table 5.

Interaction among genetic determinants on risks for cholangiocarcinoma

Genetic determinant		Genetic determinant		OR	95%CI		P value	Ref.	Ethnic group
					LL	UL
MTHFR C677T1	CC	TSER2	2R (-)	1	Reference			Ko et al[17] 2006	South Korean
	CC		2R (+)3	5.38	1.23	23.56	0.026
	CT		2R (-)	1.08	0.68	1.07
	CT		2R (+)3	1.19	0.71	2.01
	TT		2R (-)	1.02	0.7	1.5
	TT		2R (+)3	1.24	0.9	1.71
hOGG1(Codon326)	Ser/Ser	GSTM1	wild	1	Reference			Zeng et al[18] 2013	Thai
	Ser/Ser + Cys/Cys		wild	0.06	0.01	0.54	0.01
	Ser/Ser		null	0.06	0.01	0.53	0.01
	Ser/Ser + Cys/Cys		null	0.14	0.02	1.08	0.06

¹5,10-Methylenetetrahydrofolate reductase;

²Thymidylate synthase enhancer region;

³Including 2R2R and 2R3R.