Table 2.
Top Two Genes for Each Endophenotype with Most Significant SKAT Associations
| Endophenotype | Gene | Chr | No. SNPs with MAF < .05 |
Bonferroni correction |
p value |
|---|---|---|---|---|---|
| P3 | BIN3 | 8 | 2 | 3.4e-6 | 4.9e-5 |
| TRIP10 | 19 | 9 | 3.4e-6 | 6.9e-5 | |
| gP3 | KARS | 16 | 8 | 3.5e-6 | 7.7e-5 |
| ZNF560 | 19 | 10 | 3.5e-6 | 9.1e-5 | |
| SAC | ANXA3 | 4 | 8 | 3.4e-6 | 1.2e-5 |
| GALM | 2 | 4 | 3.4e-6 | 4.3e-5 | |
| SCL | DEFB116 | 20 | 2 | 3.4e-6 | 1.0e-5 |
| C6orf221 | 6 | 1 | 3.4e-6 | 1.1e-4 | |
| fSCR | CCT6A | 7 | 3 | 3.5e-6 | 9.2e-6 |
| FAM180A | 7 | 2 | 3.5e-6 | 3.3e-5 | |
| aSCR | RNF126 | 19 | 4 | 3.5e-6 | 1.0e-4 |
| MEPE | 4 | 6 | 3.5e-6 | 1.1e-4 | |
| EDA | ZNF691 | 1 | 2 | 3.4e-6 | 3.6e-5 |
| DEFB116 | 20 | 2 | 3.4e-6 | 4.1e-5 | |
| STRTL | GRID2IP | 7 | 4 | 3.4e-6 | 3.0e-5 |
| PAPSS1 | 4 | 4 | 3.4e-6 | 6.0e-5 | |
| aSTRTL | KCNA3 | 1 | 2 | 3.4e-6 | 6.7e-5 |
| C1orf43 | 1 | 2 | 3.4e-6 | 1.6e-4 | |
| pSTRTL | PNPLA7 | 9 | 22 | 3.5e-6 | 1.6e-6 |
| PHF1 | 6 | 2 | 3.5e-6 | 5.7e-5 | |
| αPower | OR5H2 | 3 | 7 | 3.4e-6 | 1.0e-5 |
| HSPB3 | 5 | 3 | 3.4e-6 | 9.3e-5 | |
| βPower | C9orf9 | 9 | 2 | 3.4e-6 | 1.9e-5 |
| SPINT1 | 15 | 11 | 3.4e-6 | 3.7e-5 | |
| θPower | CD5L | 1 | 5 | 3.4e-6 | 8.0e-5 |
| OCEL1 | 19 | 2 | 3.4e-6 | 9.6e-5 | |
| δPower | ACOT13 | 6 | 2 | 3.4e-6 | 3.1e-4 |
| KRIT1 | 7 | 3 | 3.4e-6 | 3.5e-4 | |
| totPower | OCEL1 | 19 | 2 | 3.4e-6 | 9.0e-5 |
| HSPB3 | 5 | 3 | 3.4e-6 | 2.2e-4 | |
| αPowerO1O2 | CALCOCO2 | 12 | 6 | 3.4e-6 | 8.8e-5 |
| ATF7IP2 | 16 | 6 | 3.4e-6 | 9.0e-5 | |
| αFreqO1O2 | SMAD1 | 4 | 2 | 3.4e-6 | 3.8e-5 |
| C15orf2 | 15 | 13 | 3.4e-6 | 7.3e-5 |
Note. All abbreviations are defined in Table 1. Genes with a burden allele count < 3 were not considered in arriving at this Bonferroni correction. SKAT = sequence kernel association test (Wu et al., 2011).