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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: EcoSal Plus. 2012 Nov;5(1):10.1128/ecosalplus.7.2.5. doi: 10.1128/ecosalplus.7.2.5

FIGURE 12.

FIGURE 12

VSP Repair. The asterisk above the second cytosine in the top sequence denotes a 5-meCyt residue that can deaminate to form a T-G mismatch (center). In the reverse reaction, VSP repair restores the original sequence, and Dcm methylates the appropriate cytosine. The middle sequence can undergo two additional non-reversible reactions. If the mismatched DNA is replicated before repair, one of the daughter chromosomes will inherit a CG to TA mutation. Alternatively, the mismatched substrate is acted upon by mismatch repair converting the CG into a TA base pair.