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Model of integration and oligomerization of Bax on MOM. In a healthy cell, Bax can bind to the MOM as monomer and dimer. After the induction of apoptosis, Bax undergoes two steps to form pore on MOM. Bax is activated by tBid and tends to form tetramer. Subsequently, the multimeric complex inserts into the MOM to cause its permeabilization. Bcl-xL inhibits this process by translocating Bax from MOM to cytosol.
