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IGF2 co-localizes with the insulin secretory granules. A, subcellular fractionation of MIN6 cells homogenates by ultracentrifugation on a 20–50% sucrose density gradient. Each gradient fraction was analyzed for protein and sucrose concentration. B, insulin content of each fraction. C, Western blot immunodetection of mature IGF2, pro-IGF2, and synaptophysin in each gradient fraction. The mature form of IGF2 co-localizes with the insulin granule fractions.
