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Proposed mechanism of inhibition for peracetylated 2-acetylamino-2-deoxy-3-O-methyl-d-mannose (10a). 10a is taken up by cells and converted to the corresponding non-peracetylated sugar (8a) by unspecific esterases. 8a inhibits the kinase domain of the bifunctional UDP-GlcNAc-2-epimerase/ManNAc kinase (GNE/MNK). Inhibition of the MNK lowers the de novo biosynthesis of sialic acid. The depicted glycan (3′-sialyllactose) is representative for sialylated glycans in general.
