Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 6;289(46):32109–32120. doi: 10.1074/jbc.M114.577510

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 10. — Forced disruption of F-actin restores the insulinotropic effects of GIP. A, representative membrane capacitance traces (left) from mouse β-cells infected with Adsh-scram (gray lines) or Adsh-p110γ (black lines), treated with GIP (100 nmol/liter, 1 h) and with 10 μmol/liter latrunculin B included in the patch pipette. At right is the average capacitance response over the course of the depolarization trains. B, glucose-stimulated insulin secretion in the presence of GIP (100 nmol/liter) and/or latrunculin B (10 μmol/liter) was measured from mouse islets treated overnight with either DMSO (open bars) or AS604850 (1 μmol/liter) (black bars). *, p < 0.05 as indicated.