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. 2014 Oct 6;289(46):32109–32120. doi: 10.1074/jbc.M114.577510

FIGURE 2.

FIGURE 2.

p110γ inhibition impairs GIP-R, but not GLP-1-R-stimulated insulin secretion from human islets. A–F, glucose-stimulated (HG) and GIP-stimulated (100 nmol/liter; 1 h; left panels) or Ex-4-stimulated (100 nmol/liter; 1 h; right panels) insulin secretion was measured from human islets treated overnight with either DMSO (open circles) or AS604850 (1 μmol/liter; black circles). Each individual donor is shown in a separate panel. G, averaged secretory responses to glucose alone (open bars) and together with GIP (100 nmol/liter; gray bars) or Ex-4 (100 nmol/liter; black bars) from the six donors, shown as the stimulation index (fold increase over a low glucose control). *, p < 0.5; **, p < 0.01 as indicated; ns, non significant.