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. 2014 Oct 6;289(46):32109–32120. doi: 10.1074/jbc.M114.577510

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — p110γ inhibition impairs GIP-potentiated exocytosis from mouse β-cells. A, representative capacitance recordings (left panel) and averaged cumulative capacitance responses (right panel) from mouse β-cells treated overnight with vehicle DMSO (gray lines, open circles) or AS604850 (1 μmol/liter; black lines, black circles). B, shows the same as A, except cells were additionally treated with GIP (100 nmol/liter; 1 h). C, shows the same as A, except cells were additionally treated with Ex-4 (100 nmol/liter; 1 h). *, p < 0.5; **, p < 0.01.