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p110γ inhibition impairs GIP-potentiated exocytosis from human β-cells. A, representative capacitance recordings (left panel) and averaged cumulative capacitance responses (right panel) from human β-cells treated overnight with vehicle DMSO (gray lines, open circles) or AS604850 (1 μmol/liter; black lines, black circles). B, shows the same as A, except cells were additionally treated with GIP (100 nmol/liter; 1 h). **, p < 0.01; ***, p < 0.001.
