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. 2014 Oct 6;289(46):32109–32120. doi: 10.1074/jbc.M114.577510

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — GIP-R and GLP-1-R activation induces actin depolymerization in mouse β-cells. A, dispersed mouse β-cells (in 11 mmol/liter glucose) were treated with water control, GIP (100 nmol/liter), or latrunculin B (10 μmol/liter) for indicated time periods and subsequently fixed with Z-FIX. Cells were stained for insulin (red) and F-actin (green). Representative images are shown at top with intensity line scans for F-actin staining below. B, average peak actin intensities following treatments are shown. C and D, the same as A and B, except cells were treated with Ex-4 (100 nmol/liter) instead of GIP. **, p < 0.01; ***, p < 0.001 compared with the water control.