FIGURE 9.

Immunostaining of human AD brain (a) and 3×TgAD mouse brain (b) with mOC antibodies. The 40-μm-thick serial sections from 14-month-old 3×TgAD mice were stained with the 23 mOC antibodies and 6E10. Some of the antibodies reacted with intracellular aggregates; some were specific to extracellular plaques, and some recognized vascular amyloid. For antibodies showing reactivity with more than one type of aggregate, we have included images representative of reactivity with each type of aggregate. Magnification: ×40.