TABLE 2.
Concentrations of acyl-CoAs catabolized from HNA via ω- and ω-1-oxidation from rat livers and hearts perfused with [3,4-13C2]HNA
| Acyl-CoAs | m/z | Liver | Heart | ω-/ω-1-Metabolites |
|---|---|---|---|---|
| nmol/g | nmol/g | |||
| HNA-CoA | 926 (M2) | 15.0 ± 5.3 | 7.6 ± 2.4 | |
| 4,9-Dihydroxynonanoyl-CoA | 942 (M2) | 0.5 ± 0.2 | ω | |
| 4,8-Dihydroxynonanoyl-CoA | 942 (M2) | 0.1 ± 0.05 | ω-1 | |
| 8-OH-4-phospho-nonanoyl-CoA | 1022 (M2) | 0.2 ± 0.05 | ω-1 | |
| 4-OH-nonenodioyl-CoA (lactone) | 938 (M2) | 0.5 ± 0.1 | ω | |
| OTHFPA-CoA | 910 (M2) | 118.0 ± 25.8 | 0.09 ± 0.02 | ω |
| 5-OH-hexanoyl-CoA | 883 (M1) | 0.5 ± 0.1 | ω-1 | |
| 6-OH-heptanoyl-CoA | 898 (M2) | 0.4 ± 0.2 | ω-1 | |
| 4-OH-pentanoyl-CoA | 868 (M0) | 1.8 ± 0.49 | ω-1 | |
| 4-Phosphopentanoyl-CoA | 948 (M0) | 0.5 ± 0.2 | ω-1 |