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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: J Immunol. 2000 Jun 15;164(12):6503–6508. doi: 10.4049/jimmunol.164.12.6503

FIGURE 1.

FIGURE 1

PPARγ activators inhibit IFN-γ-induced CXC chemokine mRNA expression in human ECs. A, Representative Northern blot analysis of ECs treated for 12 h with IFN-γ (100 U/ml) and PPARγ activators (10 μM 15d-PGJ2, 10 μM troglitazone (trogl), 10 μM BRL49653 (BRL); left panel) or with PPARα activators (30 μM DHA, 30 μM EPA, 250 μM WY14643 (WY); right panel). Ethanol (ETOH) as a solvent for PPAR activators served as control. B, Densitometry analysis of three independent Northern blot experiments described in A. Results of chemokine expression were normalized to GAPDH and are expressed as percent of IFN-γ-stimulated cells (% control). Bars represent mean ± SEM. *, p < 0.05; **, p < 0.01; vs IFN-γ-stimulated cells.