Table 1. Top 10 of consistently up- or downregulated mature miRNAs.

Ten most downregulated miRNAs				Ten most upregulated miRNAs
mmu-miRNA	Fold down in Adar2−/−	P-value	Avg. read number/RPM	mmu-miRNA	Fold up in Adar2−/−	P-value	Avg. read number/RPM
miR-497*	−2.59	0.0034	2173/104	miR-335-5p	2.76	0.0841	16070/772
miR-1247*	−1.59	0.0027	155/7	miR-15b	2.46	0.0941	124/6
miR-1298*	−1.55	0.0492	3463/166	miR-98	2.27	0.0986	1911/92
miR-495*	−1.54	0.0286	267/13	miR-467a*	2.07	0.0311	266/13
miR-99b	−1.54	0.031	167587/8053	miR-872*	2.01	0.0831	160/8
miR-126-5p	−1.48	0.0604	85213/4095	miR-467d*	1.92	0.0364	1033/50
miR-128-1*	−1.44	0.0023	1636/79	miR-540-5p	1.9	0.0475	887/43
miR-376a*	−1.44	0.0707	7035/338	miR-337-3p	1.89	0.0178	139/7
miR-129-5p	−1.43	0.0805	25055/1204	miR-3107	1.88	0.0178	1657/80
miR-1937a	−1.42	0.0257	223/11	miR-486	1.88	0.0178	1657/80

Only miRNAs with a minimum of 1.3-fold up-or downregulation were considered (Students t-test: P < 0.1). Underlined miRNAs were found edited in this study. A complete list of up- or downregulated miRNAs can be found in Supplementary Table S1.