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. 2014 Sep 26;42(19):12041–12051. doi: 10.1093/nar/gku872

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — MiR-101 is mainly transcribed from the human miR-101-2 and mouse miR-101b loci. (A) Structure and sequence of human miR-101 gene. Sequence data were obtained from the UCSC genome browser database (hg18) and miRBase (release 20). The transcription start site and exon borders of the miR-101-1 gene are taken from published data (24). Seed region of miR-101 was underlined. The nucleotide that is different in mouse miR-101b is indicated in gray color. (B) Expression of the primary transcripts of miR-101-1 and miR-101-2 genes in normal human liver and hepatoma cell lines. The level of pri-miR-101-1 in the normal human liver (661N) was set to 1. (C) Expression of mature miR-101a and miR-101b in various mouse tissues. Expression of miR-101a in the liver was set to 1.