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| dATP opposite 8-oxo-dG | kcat (min−1) | KM,dNTP (μM) | kcat/KM,dNTP (min−1 μM−1) |
|---|---|---|---|
| No WRN | 19.3 ± 0.6 | 2.8 ± 0.5 | 6.9 |
| WRN1-1432 | 17.9 ± 0.8 | 2.0 ± 0.5 | 8.9 |
| WRN1-1092/E84A | 18.2 ± 0.6 | 1.9 ± 0.4 | 9.5 |
| WRN500-1150 | 22.1 ± 2.0 | 3.9 ± 1.1 | 5.6 |
| WRN949-1092 | 20.0 ± 1.3 | 4.0 ± 1.1 | 5.0 |
| WRN1-333 | 13.2 ± 0.5 | 1.5 ± 0.4 | 8.8 |
Kinetic parameters were obtained as indicated in Table 1.
