2013 |
Dry Eye as Mucosal Autoimmune Disease64
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Dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface. |
2013 |
Toll-Like Receptor Expression and Activation in Mice with Experimental Dry Eye 68
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Toll-like receptors (TLRs) are involved in dysfunctional tear syndrome (DTS) inflammation |
2012 |
Autoantibodies Contribute to the Immuno-pathogenesis of Experimental Dry Eye Disease 69
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Autoantibody deposition within the ocular surface tissues contributes to the predominantly T-cell-mediated immunopathogenesis of dry eye disease. |
2012 |
Deletion of interferon-gamma Delays the Onset and Deverity of Dacryoadenitis in CD25KO Mice 70
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The deletion of IFN-γ in the CD25KO mice strain (γDKO ) delays glandular destruction and preserves glandular function. M3R autoantibodies increased with aging in both the γDKO and the CD25KO strains. The decrease in LG function in yDKO correlated with the degree of T-cell infiltration and the presence of M3R autoantibodies. |
2012 |
Resolvin El (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye 71
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Endogenous resolvins and resolvin analogues may have potential utility in the treatment of dry eye. |
2011 |
Disruption of TGF-beta Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca 72
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Disruption of TGF-β signaling in CD4(+) T cells causes paradoxical improvement of dry eye disease in mice subjected to desiccating stress. |
2011 |
Homeostatic Control of Conjunctival Mucosal Goblet Cells by NKT-derived IL-13 73
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NKT cells are major sources of IL-13 in the conjunctival mucosa that regulates GC homeostasis. |
2010 |
Induction of Th17 Differentiation by Corneal Epithelial-Derived Cytokines 74
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Th17 differentiation can be promoted by cytokines produced by corneal epithelium that are exposed to hyperosmotic, microbial, and inflammatory stimuli. |
2010 |
Autoimmunity at the Ocular Surface: Pathogenesis and Regulation 75
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Environmental, microbial and endogenous stress, antigen localization, and genetic factors provide the triggers underlying the immunological events that shape the outcome of the diverse spectrum of autoimmune-based ocular surface disorders. |
2010 |
An Immunoprotective Privilege of Corneal Epithelial Stem Cells Against Th17 Inflammatory Stress by Producing Glial Cell-Derived neurotrophic Factor 76
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Limbal progenitor cell-produced neurotrophic factor GDNF suppresses IL-17-mediated inflammation via NF-κB signaling pathway. This may represent a unique immunoprotective property of imbal stem cells against inflammatory challenges on the ocular surface. |
2009 |
Spontaneous T Cell Mediated Keratoconjunctivitis in Aire-Deficient Mice 77
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Aire-deficiency leads to infiltration of CD4(+) and CD8(+) T cells on the ocular surface and meibomian glands, accompanied by goblet cell loss. Desiccating stress promotes this proinflammatory milieu. Immune-mediated mechanisms play a role in the severe blepharitis andkeratoconjunctivitis in the murine model of APECED. |