Table 4.
Summary statistics for CORE-PD study. Total number of first-degree relatives (n), number of parents, siblings, and children, and percentage of first-degree relatives who have the specified mixture-proportion (p; 1 − p), where p is the probability of a relative carrying at least one copy of mutation.
| Mixture proportion (%) | |||||||
|---|---|---|---|---|---|---|---|
| n | Parents | Siblings | Children | (1,0) | (0,1) | (0.5,0.5) | |
| Carrier vs. Non-Carrier | 355 | 63 | 182 | 110 | 31.5 | 64.8 | 3.7 |
| Compound Heterozygous Carrier or Homozygous Carrier* | 17 | 1 | 15 | 1 | 100.0 | 0 | 0 |
| Heterozygous Carrier vs. Non-Carrier | 338 | 62 | 167 | 109 | 28.1 | 68.1 | 3.8 |
*
Genotype for subjects in this group are known.