Table 3.

 Clinical outcomes in patients with ST segment elevation myocardial infarction with preserved left ventricular systolic function according to treatment during follow-up. Figures are numbers (percentage) of patients and hazard ratios (95% confidence interval)

	Angiotensin receptor blocker (n=1185)	Comparison group*	Unadjusted			Adjusted†
			HR (95% CI)	P value		HR* (95% CI)	P value
Comparison with ACE inhibitor (total population=5749)
Cardiac death or MI	21 (1.8)	77 (1.7)	1.02 (0.63 to 1.66)	0.92		0.94 (0.58 to 1.53)	0.79
All cause death	32 (2.7)	64 (1.4)	1.85 (1.21 to 2.83)	0.01		1.54 (1.00 to 2.37)	0.05
Cardiac death	15 (1.3)	35 (0.8)	1.61 (0.88 to 2.96)	0.12		1.33 (0.72 to 2.46)	0.36
Myocardial infarction	7 (0.6)	43 (0.9)	0.61 (0.27 to 1.35)	0.22		0.59 (0.26 to 1.31)	0.19
Comparison with no renin angiotensin system blocker (total n=2134)
Cardiac death or MI	21 (1.8)	33 (3.5)	0.44 (0.25 to 0.76)	0.004		0.49 (0.27 to 0.87)	0.02
All cause death	32 (2.7)	29 (3.1)	0.74 (0.45 to 1.23)	0.25		0.82 (0.48 to 1.40)	0.47
Cardiac death	15 (1.3)	18 (1.9)	0.57 (0.29 to 1.13)	0.11		0.69 (0.33 to 1.44)	0.32
Myocardial infarction	7 (0.6)	15 (1.6)	0.33 (0.13 to 0.81)	0.02		0.29 (0.11 to 0.76)	0.01

*n=4564 for ACE inhibitor group and 949 for no renin angiotensin system blocker group

†For comparison with ACE inhibitor group, adjusted for age, sex, hypertension, previous history of myocardial infarction, creatinine, left anterior descending artery as infarct related artery, use of clopidogrel, β blocker, and angiotensin receptor blocker at discharge. For comparison with no renin angiotensin system blocker group, adjusted for hypertension, Killip class ≥III on admission, left anterior descending artery as infarct related artery, post-procedural TIMI flow grade 3 on culprit vessel, use of vasopressor and intra-aortic balloon pump during admission, use of aspirin, clopidogrel, β blocker, and angiotensin receptor blocker at discharge.