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DHQase enzymes. (a) The reaction catalyzed by DHQase. LigPlot (Wallace et al., 1996 ▶) representation of interactions in the active site of a prototypical (b) type 1 enzyme and (c) type II enzyme in complex with 3-dehydroshikimate (DHS) reveals differences in the two classes of enzymes. The representative type I structure is PDB entry 4gug from S. enterica (Light et al., 2013 ▶) while the representative type II structure is PDB entry 3n59 from M. tuberculosis (Dias et al., 2011 ▶).
