Figure 1.

Structure of the KSHV LANA CTD dimer. (a) Van der Waals surface representation colour-coding the electrostatic potential. Characteristic features are highlighted. (b) Cartoon representation colour-coding triple alanine-scanning mutagenesis data regarding sequence-specific DNA binding in electrophoretic mobility shift assays (Kelley-Clarke et al., 2007 ▶). Magenta, mutants are impaired in DNA binding; green, mutants display apparently stronger DNA binding; grey, not tested. Point mutations implemented in our LANA CTD constructs are indicated on the left monomer. The twofold symmetry axis is shown as a dashed line.