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. 2004 Jun 15;18(12):1385–1390. doi: 10.1101/gad.287404

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Copyright © 2004, Cold Spring Harbor Laboratory Press

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Figure 5. — Perturbation of the EphB/ephrinB system. (a) The pattern of EphB2 staining in crypt enterocytes, predominantly confined to the lower half of control crypts. (b) EphB2 staining throughout the aberrant crypt structure in the induced Cre⁺Apc^fl/fl mice. Arrow denotes leading edge of aberrance, where unrecombined villus cells with wild-type morphology do not stain for EphB2. (c) EphB3 staining confined to the base of control crypts. (d) EphB3 staining throughout the aberrant crypt structure in the induced Cre⁺Apc^fl/fl mice. (e,f) Ephrin B1 and B2 staining respectively of villus cells within control intestine. (g) Lack of staining for Ephrin B2 within the aberrant cells in the induced Cre⁺Apc^fl/fl mice. Arrow denotes leading edge of aberrance, where unrecombined villus cells stain for Ephrin B2.