Figure 5.

Natural killer T (NKT)-like (CD56⁺βTCR⁺) cells become more prevalent over the course of rIL-21 administration. (a) Representative contour plots of β T-cell receptor (βTCR) vs. CD56 expression on non-α-GC/CD1d-restricted cells. Numbers represent the percentage of cells in the gated region. (b) The frequency of NKT-like cells in patients administered rIL-21. (c) The frequency of mucosal-associated invariant T (MAIT) cells (CD161⁺ among βTCR⁺CD8⁺CD4⁻α-GC/CD1d tetramer⁻) was analyzed over the course of rIL-21 administration. Results were analyzed using the Wilcoxon signed rank test with a Bonferroni correction to account for the number of comparisons being made (*P<0.05).