CVP2 Is a Member of the Endonuclease/Exonuclease/Phosphatase Family.
(A) Alignment of CVP2 with other plant 5PTases. The accession number for the rice 5PTase is AA037964.
(B) CVP2 is aligned to a consensus sequence for endonuclease/exonuclease/phosphatase family members according to the NCBI conserved domain database (http://www.ncbi.nlm.nih.gov/Structure/cdd). The C-terminal part of the CVP2 protein is shown. Members with accession numbers for which the consensus sequence was derived include the following: S. pombe synaptojanin, 1I9Y_A; leptospira hemolytic protein, AAB68647; S. pombe RNA nuclease, CAB42372; C. elegans reverse transcriptase, CAB07490; catabolite repressor protein, ACC44428; Homo sapiens Type I 5PTase, Q14642; bovine DNase I, 1DNK_A; Escherichia coli Exonuclease III, 1AKO; and human endonuclease I 1DEB_B. Alignments were conducted using MacVector 7.0 (Oxford Molecular, Madison, WI). Identical residues are shaded black.