Table 2.

Pharmacokinetic Parameters of ¹⁴C-Voclosporin Following Single or Repeat (QD for 7 Days) Dose of Mixed Nanomicellar Voclosporin Formulation in Female New Zealand Albino Rabbits

Ocular Tissue(s)/Fluids & Blood	Cmax (ng eq./g)			AUC (hr* ng eq./g)			Tmax (hr)		t1/2 (hr)
	SD	RD	Ratio	SD	RD	Ratio	SD	RD	SD	RD
Aqueous Humor	6	13	2.3	45	96	2.1	0.5	0.5	-	14
Choroid/Retina	48	76	1.6	472	897	1.9	1.0	2	23	-
Cornea	1203	3382	2.8	23166	54624	2.4	8.0	0.5	-	-
Iris/Ciliary body	20	119	5.8	382	1952	5.1	24.0	1	-	-
Lacrimal Gland	31	120	3.9	416	1109	2.7	2.0	4	-	6
Lens	4	26	6.7	47	356	7.5	24.0	0.5	-	-
Lower Bulbar	1810	2929	1.6	12029	16585	1.4	0.5	0.5	10	7
Conjunctiva Lower Eyelid	20814	41635	2.0	207630	358791	1.7	1.0	0.5	-	-
Nictitating membrane	1716	2468	1.4	12135	15964	1.3	0.5	0.5	7	8
Optic Nerve	83	164	2.0	569	1805	3.2	0.5	0.5	-	16
Sclera	223	367	1.6	2646	3825	1.4	0.5	0.5	-	16
Submandibular	74	120	1.6	893	1190	1.3	2.0	2	-	-
Lymph Node Tear	20246	30904	1.5	168259	230878	1.4	0.5	0.5	-	7
Upper Bulbar	2235	3170	1.4	14782	19944	1.3	0.5	0.5	7	7
Conjunctiva Upper Eyelid	9896	17500	1.8	114651	98656	0.9	1.0	0.5	-	4
Vitreous Humor	2	2	1	27	23	0.9	8.0	4	-	-
Blood	BQL	BQL	NC	NC	NC	NC	NC	NC	NC	NC

^aTime needed to achieve peak IOP increase.

^bDuration of IOP increase response (the time interval needed for the IOP to return to its normal pretreatment value).

^cApproximate values calculated from the slope ln (% increase in IOP)/Δt for the terminal points of % increase in IOPt versus t curves.

^dRatio of AUC to the value for the commercial DEX (0.1, w/v, %) eye drops.

^*Statistically significant difference as compared with commercial DEX (0.1, w/v, %) eye drops (p < 0.05).

SD = Single dose;

RD = Repeat dose;

Ratio = Repeat dose/Single Dose.;

- = Insufficient tissue concentration to determine t_1/2;

BQL = Below Quantifiable Limit (<0.1 ng/mL);

NC = Not calculated.