Table 1.

Simulation parameters. Literature sources are noted.

Variable [Unit]	Description	Normal Value	Tumor Value
Bioheat Equation, Eq. (11), (12)
ρ [kg/m3]	Tissue densitya	1050	1050
C[J kg−1K−1]	Tissue heat capacitya	3600	3600
k[W m−1K−1]	Thermal conductivitya	1.0 (0.7)	1.0
ωb[s−1]	Perfusion ratea	0.006(0.007)	0.006
Tb[°C]	Blood temperature	37	37
Ultrasound Treatment Parameters Eq. (12)
Ptap[W]	Acoustic powera	12	12
αz[m−1]	Ultrasound absorptiona	2.6	2.6
σR[mm]	Beam waist half-widtha	$1.13\left(=\frac{1.6}{\sqrt{2}}\right)$	1.13
σz[mm]	Focal spot half-lengtha	$5.27(=\frac{7}{1.5}{\sigma }_R)$	5.27
Fluid Transfer Equation, Eqs. (1) – (3), (6)
Tc[°C]	Transition temperatureb	49	49
λ,μ [mmHg]	Lamé coefficientsc	684, 15.2	684, 15.2
H0[mmHg]	Aggregate modulus	714 (= λ + 2μ)	714
f = −ΔH/H0	Fractional change in H	0.53	0.53
$K\left[\frac{cm}{\mathit{mmHg}s}\right]$	Fluid conductivityd	2.5× 10−7	2.5× 10−7
$L_p\left[\frac{cm}{\mathit{mmHg}s}\right]$	Filtration coefficientd	3.6 × 10−8	1.86 × 10−6
S/V[cm−1]	Vascular surface densityd	100 [50–250]	100 [50–250]
$\alpha \left[\frac{1}{\mathit{mmHg}s}\right]$	Effective filtrationd	3.6 × 10−6	1.86 × 10−4
σ	Osmotic reflection (BSA)d	0.91	8.7× 10−5
πv, πi [mmHg]	Osmotic pressuresd	20, 10	19.8, 17.3
PSS[mmHg]	Steady state IFP	1.0	10
ϕ0	Volume fraction of fluide	0.13–0.3	0.35–0.55
Solute Transport Equation, Eqs. (4), (5), (9)
D [cm2/s]	Solute diffusivityf	4.8 × 10−10	1.3 × 10−8
rF	Convection efficiency	1.0	1.0
ζeff [cm/s]	Effective permeabilityf	7.3 × 10−8	5.73 × 10−7
Σ	Effective solute reflection	0.9	0.0001
τp[hr]	Solute plasma half-lifef	72	72

^aData taken from O’Neill et al (2012)

^bData taken from O’Neill et al (2013)

^cData taken from Netti et al (1997)

^dData taken from Jain et al (2007)

^eData taken Jain (1987)

^fData taken from Baxter and Jain RK (1989)