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SCH-479833 and SCH-527123 inhibit melanoma growth. Eight-week-old mice were injected with highly metastatic human melanoma A375SM cells subcutaneously.Twenty-four hours after injection, mice were orally fed with SCH-479833 or SCH-527123 antagonist (100 mg/kg in 0.2 mL of 20% HPβCD) once a day for 21d. Control mice were fed with 0.2 mL vehicle (20% HPβCD) alone. Growth curve of A375SM cells in athymic nude mice treated with vehicle, SCH-479833, and SCH-527123. Average ± SE tumor volume.
