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SCH-479833 and SCH-527123 inhibit microvessel density in human melanoma tumors
| Treatments | MVD (mean ± SE) | % Inhibition | t test |
|---|---|---|---|
| HPβCD | 8.00 ± 0.33 | ||
| SCH-479833 | 5.22 ± 0.33 | 35 | P < 0.05 |
| SCH-527123 | 4.44 ± 0.22 | 45 | P < 0.05 |
NOTE: Immunohistochemical staining for microvessel using anti-GS-IB4 was analyzed as described in Materials and Methods. Microvessel density was quantitated microscopically with a 5 × 5 reticle grid at ×400 magnification.
