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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: Mol Membr Biol. 2010 Jun 17;27(8):412–427. doi: 10.3109/09687688.2010.495354

Figure 3. Two models for quality control receptor-substrate targeting to an ER membrane ERAD complex.

Figure 3

A) ERAD receptors recognize aberrant cargo displaying carbohydrate based ERAD signals using their sugar-binding domains (MRH or mannosidase-like domains). The receptor-substrate complex is then delivered to an ERAD complex in the ER membrane consisting of an adapter protein, an E3 ligase and a translocation channel or translocon. B) In an alternative model for selection and delivery, the ERAD receptor selects client proteins based on the folding status of the protein through protein-protein interactions. Once a misfolded protein has been recognized the receptor uses its sugar-binding domain to dock to a glycan on the adapter protein to support delivery of the substrate to the ERAD complex.