Table 3.

Incidence of specific forms of invasive pneumococcal disease in children

Citation (country)	Methodology	Risk category	Age range (years [median])	N *	Time period	Incidence (per 100,000 patient-years)
Meningitis
Biernath 2006 (USA) 30	Cohort study	Cochlear implants	< 6 [55 months]	4265	97–04	120
Wilson-Clark 2006 (Canada) 31b	Postal survey	Cochlear implants	<18 [–]	482	95–02	290
			<6 [–]
			< 18 [–]	–	95–98	220
					99–02	400
			< 6 [–]	–	95–98	150
					99–02	310
Melegaro 2006 (UK) 29	National hospital database study †	General high-risk patients	< 1 month [–]	–	95–00	15.6
			1–11 months [–]			15.3
			1–4 [–]			1.7
			5–9 [–]			0.2
			10–14 [–]			0.2
Bacteraemia
Steenhoff 2008 (PA, USA) 24	Retrospective cohort study	HIV infection	–	–	08–09	398

^*Total number of patients in analysis.

^†Includes some bacterial meningitis cases related to Neisseria meningitidis or of unknown bacterial type.

HIV, human immunodeficiency virus.