Figure 6. Survival curves after challenge of infant mice.

Infant mice (9–10 mice per group) were challenge with Inaba (A) or Ogawa (B) bacteria mixed with pooled serum from adult CD1 mice orally immunized with formalin–killed MS1568 (open circles with dashed lines), Dukoral (triangles) or as control serum from unimmunized mice (open squares). Results show that mice challenged with either Inaba or Ogawa bacteria mixed with serum from MS1568 and Dukoral, respectively, had reduced mortality (p<0.0001) compared to mice challenged with bacteria mixed with control serum.