Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Nov 14;464(Pt 2):231–239. doi: 10.1042/BJ20140606

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

(A) The conformation of the AKAP-Lbc DH domain GEF switch region (coloured in magenta) when bound to RhoA. RhoA is coloured with red α-helices and yellow β-strands with its switch I region in green. The DH domain of AKAP-Lbc is coloured blue. (B) The conformation of the DH domain when not bound to RhoA. (C and D) The conformation of the equivalent regions in LARG when bound to RhoA (C) and p115-RhoGEF when not bound to RhoA (D). (E) Sequence alignment of the GEF switch regions of AKAP-Lbc and three homologous RhoGEF domains. Residues important for the packing of the GEF switch region are marked with asterisks below the alignment.