Table 1.

Pharmacokinetic Parameters Derived

Parameter	Description
Cmax	Maximum observed drug concentration
tmax	Time to reach Cmax
AUC0-t	Area under the drug concentration time curve from time 0 to time t, where t is the time of the last measurable concentration [Cp], calculated using the linear trapezoidal rule
AUC0-∞	Area under the drug concentration time curve from time 0 to infinity, calculated as AUC0-∞ = AUC0-t + Cp/λZ
AUC0-15 min	Area under the drug concentration time curve from time 0 to 15 minutes
AUC0-30 min	Area under the drug concentration time curve from time 0 to 30 minutes
t	Terminal elimination half-life, calculated as ln(2)/λZ where λZ is the apparent first-order terminal elimination rate constant calculated from a semi-log plot of the concentration vs time curve by linear least-squares regression analysis
λZ	Terminal elimination rate constant
AUC%extrap	Percentage of AUC0-∞ extrapolated from Cp to infinity, calculated as 100 × (1 − [AUC0-t/ AUC0-∞])

AUC = area under the curve.