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. 2014 Jan 23;53(8):2130–2133. doi: 10.1002/anie.201308636

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© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Inhibition of meropenem hydrolysis in the presence of NDM-1 E. coli cells by L-captopril (A) and EDTA (B) at various concentrations, and IC₅₀ measurements for L-captopril (C) and EDTA (D). For each experiment, the NDM-1 E. coli cells (OD₆₀₀=5.0) were first incubated with the inhibitor for 10 min and 100 μM meropenem was subsequently added.