Figure 1.

ADP and ADPβS induce BSM contraction with dose dependence. A, D) Representative traces of BSM responses to indicated concentrations of ADP (A) and ADPβS (D). ADP or ADPβS was quickly washed out 3 times after each response, and there was a 15-min interval between each addition. B, E) Summary of force change (peak force minus baseline) with increasing ADP (B) or ADPβS (E) concentrations. *P < 0.05. C, F) Nonlinear regression of ADP (C) and ADPβS (F) dose and contraction force response using the GraphPad Prism dose-response-stimulation program.