Skip to main content
. 2014 Dec;28(12):5288–5298. doi: 10.1096/fj.14-255885

Figure 2.

Figure 2.

P2Y12R selective antagonist blocks ADP-induced BSM contraction. In all panels, ADP was used at 100 μM. A) Effects of selective P2Y1 receptor agonist (10 μM MRS 2365) and antagonist (2 μM MRS 2500) on BSM contractility. B) Effects of selective P2Y2 receptor agonist (20 μM MRS 2768) on BSM contractility. C) Effects of selective P2Y6 receptor antagonist (5 μM MRS 2578) on BSM contractility. D) Effects of selective P2Y12 receptor antagonist (25 μM PSB 0739) on BSM contractility. E) Effects of selective P2Y13 receptor antagonist (1 μM MRS 2211) on BSM contractility. Only selective P2Y12 receptor antagonist PSB 0739 blocks ADP-induced BSM contraction. Antagonists were added to BSM 15 min before ADP stimulation. *P < 0.05.