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. 2014 Nov 14;9(11):e112665. doi: 10.1371/journal.pone.0112665

Table 1. Prevalence of risk alleles in intervention group (n = 92) and associated risk.

Dietary Component Gene Risk Allele Non-Risk Allele Associated Risk
n (%)
Caffeine CYP1A2 48 (52) 44 (48) Increased risk of myocardial infarction and hypertension when consuming above 200 mg of caffeine/day
General recommendation: ≤300 mg/day for women of child-bearing age
≤400 mg/day for other adults
Targeted Recommendation: ≤200 mg/day for those with risk version of CYP1A2
Vitamin C GSTM1 + GSTT1 52 (57) 40 (43) Increased risk of serum ascorbic acid deficiency when consuming below the RDA for vitamin C
General recommendation: RDAa for women: ≥75 mg/day
RDA for men: ≥90 mg/day
Targeted Recommendation: Same as general recommendation
Added Sugars TAS1R2 41 (45) 51 (55) Increased risk of over-consuming sugars
General recommendation: ≤10% energy/day
Targeted Recommendation: Same as general recommendation
Sodium ACE 64 (70) 28 (30) Increased risk of sodium-sensitive hypertension when consuming above the AI for sodium
General recommendation: ULb: ≤2300 mg/day
Targeted Recommendation: AIc: ≤1500 mg/day for those with risk version of ACE
a

RDA: Recommended dietary allowance.

b

UL: Tolerable upper intake level.

c

AI: Adequate intake.