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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Genes Chromosomes Cancer. 2014 Sep 18;54(1):28–38. doi: 10.1002/gcc.22215

Figure 2. Histologic and FISH findings of hybrid SEF/LGFMS.

Figure 2

A–C. SEF7 showing predominant LGFMS background with scattered nodular areas of SEF (FUS-CREB3L2 positive, A, 40×); typical LGFMS morphology with bland spindle cells arranged in fascicles (B, 100×) and high power of SEF showing a predominant SBRCT phenotype (C, 200×). D–G. A hybrid SEF/LGFMS (SEF8), with distinctive hyalinizing giant rosettes (FUS-CREB3L2 positive, D, 100×), showing areas of classic LGFMS (E, 100×), as well as solid areas of SEF (F, 100×); MUC4 strong and diffuse immunoreactivity (G, 100×). FISH showing (H, SEF/LGFMS4) and CREB3L2 (I, SEF/LGFMS4) split-apart signals (arrows) in SEF (red, centromeric; green telomeric)