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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Int J Cancer. 2014 Jun 28;136(3):536–546. doi: 10.1002/ijc.29028

Figure 3. Blocking TGFβ signaling attenuates the tumor suppressor activity of KLF5 in prostate cancer cells.

Figure 3

Tumor cells expressing KLF5, acetylation-deficient K369R or the vector control (PLHCX) were subcutaneously injected into nude mice, and tumors were surgically isolated at day 42 for PC-3 cells (a) and day 34 for DU 145 cells (b) post injection. The TGFβ receptor inhibitor SB431542 (SB) was administered to mice via intraperitoneal injection. Average tumor weights (grams, g) are indicated by bar figures at left, with the standard errors indicated at the top of bars. Images of all tumors are shown at right. *, P<0.05; **, P<0.01; ***, P<0.0001.