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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Chem Biol. 2014 Oct 26;10(12):1066–1072. doi: 10.1038/nchembio.1666

Table 2.

Docking rank and in vitro IC50 values for cyanoacrylamides 19 – 26 against RSK2 WT and T493M mutant C-terminal kinase domain.

Compound DOCK rank IC50 (μM)
RSK2 WT RSK2 T493M
19 66 50.4 27.9
20 96 7 5.2
21 122 1.1 0.43
22 132 3.3 6.8
23 142 12.7 6.4
24 200 1.2 0.37
25 368 >100 >100
26 391 6 7.1