Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Appl Immunohistochem Mol Morphol. 2014 Nov-Dec;22(10):748–755. doi: 10.1097/PAI.0000000000000046

Figure 2. FLM staining in normal and MEN1 specimens.

Figure 2

Panel A - Section of normal pancreas showing evenly distributed and regularly sized islets with approximately 50% immunoreactive cells using the FLM antibody (Original magnification ×40). Panel B - Section of pancreatic tissue surrounding a neuroendocrine tumor in a resection from an MEN1 patient. IHC staining demonstrates FLM-immunoreactive cells located at the periphery of islets that appear unremarkable when examined by light microscopy (Original magnification ×40). Panel C - Section from a pancreatectomy specimen of an MEN1 patient demonstrates somewhat enlarged islets with peripheral FLM-immunoreactive cells, and a hyperplastic islet in the center with FLM-immunoreactive cells (Original magnification ×40). Panel D - Section of pancreatic tissue from an MEN1 patient demonstrates increased numbers of periductal endocrine cells and a small islet budding from the duct (arrow), enlarged hypertrophic islets, and a small tumorlet that are all immunoreactive with FLM (Original magnification ×100).