Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2016 Jun 21.

Published in final edited form as: J Theor Biol. 2014 May 14;375:77–87. doi: 10.1016/j.jtbi.2014.05.003

Fig. 5 — Heat-map simulations of the scaled model, described by Eqs. (9)–(11), at κ = 5 × 10⁻⁹(day cell)⁻¹. The 10-year time evolution of ₁ (A1–A3), ₂ (B1–B3), ₃ (C1–C3) and β (D1–D3) are displayed. The color-coding in each panel is quantified by the color-bars on the top of each column. The simulations are performed by applying LHS over the following ranges: k₁ ∈ [1, 3] (A1–D1), k₂ ∈ [0.5, 2] (A2–D2) and k₃ ∈ [0.01, 0.5] (A3–D3), given that the inequality k₁ ≥ k₂ ≥ k₃ is always maintained. Notice that the random sampling performed by LHS makes small perturbations in the values of k_i, i = 1, 2, 3, have significant implications on the number of surviving beta-cells. (For interpretation of the references to color in this figure caption, the reader is referred to the web version of this paper.)

Inline graphic — Heat-map simulations of the scaled model, described by Eqs. (9)–(11), at κ = 5 × 10⁻⁹(day cell)⁻¹. The 10-year time evolution of ₁ (A1–A3), ₂ (B1–B3), ₃ (C1–C3) and β (D1–D3) are displayed. The color-coding in each panel is quantified by the color-bars on the top of each column. The simulations are performed by applying LHS over the following ranges: k₁ ∈ [1, 3] (A1–D1), k₂ ∈ [0.5, 2] (A2–D2) and k₃ ∈ [0.01, 0.5] (A3–D3), given that the inequality k₁ ≥ k₂ ≥ k₃ is always maintained. Notice that the random sampling performed by LHS makes small perturbations in the values of k_i, i = 1, 2, 3, have significant implications on the number of surviving beta-cells. (For interpretation of the references to color in this figure caption, the reader is referred to the web version of this paper.)