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. 2004 Jun 1;101(23):8664–8669. doi: 10.1073/pnas.0402354101

Fig. 4.

Fig. 4.

Histological examination of mouse seminiferous tubules. (A) Hematoxylin and eosin staining of a testes section from a Bbs4+/+ mouse. Flagella are apparent in the lumen of the tubule. (B) Hematoxylin and eosin staining of a testes section from a Bbs4–/– mouse showing the absence of flagella in the lumen. (C) Toluidine blue staining of a 1-μm testes section from a Bbs4+/+ mouse showing spermatozoa with normal morphology as evidenced by the presence of flagella and condensed sperm nuclei. (D) Toluidine blue staining of a 1-μm testes section from a Bbs4–/– mouse showing the presence of condensed sperm nuclei in the absence flagella.