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Hypothesized sex-determining pathway in C. gigas compared with that in model organisms as summarized by Gamble and Zarkower (2012). For clarity, only selected key sex-specific regulators are shown. Dashed black lines indicate temporal relationships, and dashed red lines indicate hypothetical relationships based on expression data only. [Modified based on Gamble and Zarkower (2012)]. FF genotype permits sex change (Guo et al. 1998).
