Table 1. Influenza A-specific siRNA treatment inhibits influenza A/H1N1 virus replication in vivo.

Treatment*	n	Mean lung virus titer†	P value‡	Fold reduction§
siGFP	5	5.6 ± 0.4	—	—
siNP	5	3.8 ± 0.1	<0.0001	63
siPA	4	4.6 ± 0.1	<0.01	10
siNP+siPA	5	3.8 ± 0.2	<0.0001	63

—, not applicable.

^*BALB/c mice were treated as indicated and challenged with 5 × 10² TCID₅₀ of PR/8. Two days later, animals were sacrificed and lungs were collected for virus titer.

^†Expressed as log₁₀ TCID₅₀/ml ± SEM.

^‡One-way ANOVA statistical analysis on log-transformed data, followed with comparison with control (siGFP) by Dunnett's method.

^§Compared with the siGFP-treated group.