Fig. 2.

Impact of cholesterol depletion on Kir2.3–PIP2 interactions.

A. Representative Kir2.1 current traces before (red) and after (green) dialyzing neomycin into the cell through a patch pipette in a control cell (upper traces) and in a cholesterol depleted cell (lower family). B: The time courses of Kir2.1 rundown in response (100 nM–10 μM) neomycin. C: The time courses of Kir2.1 rundown in response 1 μM neomycin in control and cholesterol depleted cells (all data show means + SEM, n = 5–10 cells per condition).