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. 2014 Nov 14;9(11):e112971. doi: 10.1371/journal.pone.0112971

Figure 3. Mitochondrial protein localization and overexpression in dilated human hearts analyzed using transmission electron microscopy.

Figure 3

Influence of dilated cardiomyopathy on the amount and localization of the representative proteins involved in cardiac energy metabolism (ODPA, ETFD, DLDH, AL4A1, and ATPA), protein biosynthesis (EFTU), and stress response (PRDX3). We observed an increase in immunogold labeling in all proteins studied in DCM hearts. We also confirmed the location of all proteins analyzed and observed a similar distribution of each protein upon comparing pathological with control samples. The bar represents 100 nm. CNT, control; DCM, dilated cardiomyopathy; ODPA, pyruvate dehydrogenase E1 component subunit α, somatic form; ETFD, electron transfer flavoprotein-ubiquinone oxidoreductase; DLDH, dihydrolipoyl dehydrogenase; AL4A1, delta-1-pyrroline-5-carboxylate dehydrogenase; ATPA, ATP synthase subunit α; EFTU, elongation factor Tu; PRDX3, thioredoxin-dependent peroxide reductase.