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. 2014 Nov 14;9(11):e112971. doi: 10.1371/journal.pone.0112971

Figure 4. Levels of mRNA expression determined by RNAseq.

Figure 4

(a) mRNA levels of the ODPA gene (PDHA1), ETFD gene (ETFDH), AL4A1 gene (ALDH4A1), ATPA gene (ATP5A1), and EFTU gene (TUFM) were increased in the dilated group compared to the control group. The data are expressed as mean ± SEM in mRNA relative expression. (b) The scatter plots show the relationship between the mRNA expression of molecules altered involved in substrate utilization (PDHA1 and ETFDH) and also with other altered protein implicated in metabolic processes (ALDH4A1) and protein synthesis (TUFM). These genes showed a relevant correlation with ATP5A1, which is involved in energy production. CNT, control; DCM, dilated cardiomyopathy; ODPA, pyruvate dehydrogenase E1 component subunit α, somatic form; ETFD, electron transfer flavoprotein-ubiquinone oxidoreductase; AL4A1, delta-1-pyrroline-5-carboxylate dehydrogenase; ATPA, ATP synthase subunit α; EFTU, elongation factor Tu. *p value<0.05, **p value<0.01.