Table 3. Protein homologs to the core clock proteins of mammals.
Organism | Protein | Clock function | C. elegans homolog | E value | |
Mus musculus | PER | PER1 | central clock | F47F6.1c (LIN-42c) | 7.50E-17 |
PER2 | central clock | F47F6.1b (LIN-42b) | 2.90E-21 | ||
PER3 | central clock | F47F6.1b (LIN-42b) | 5.50E-20 | ||
BMAL | BMAL1 | central clock | C25A1.11a (AHA-1a) | 1.80E-65 | |
BMAL2 | central clock | C25A1.11a (AHA-1a) | 5.40E-63 | ||
CLK | central clock | C25A1.11a (AHA-1a) | 1.50E-17 | ||
NPAS2 | central clock | C25A1.11a (AHA-1a) | 6.80E-19 | ||
CRY | CRY1 | central clock | None | none | |
CRY2 | central clock | None | none |
These proteins are the best hits found by probabilistic inference search based on Hidden Markov Models built upon multiple protein alignments of the core clock of mammals (M. musculus). Common C. elegans names are enclosed between parenthesis when available.